Mold in the News Series

Part 5: The Links Between Mold Illness and Alzheimer’s

Cesar Collado
Dec 15, 2023

Mycotoxicosis and Fungal Infections are Emerging Cofactors in Alzheimer’s Disease Research

By Cesar Collado

There have been an increasing number of publications on the links between mold and Alzheimer’s Disease. Alzheimer’s disease is a progressive neurodegenerative disorder. It affects millions of individuals worldwide. While the exact cause of Alzheimer’s remains elusive, researchers have been investigating various factors that may contribute to its development, including the potential involvement of fungi. In recent years, emerging evidence has shed light on the intriguing connection between fungi and Alzheimer’s disease.

Mold Presence in Alzheimer’s Brains

Researchers have revealed the presence of fungal components, such as proteins and DNA, within the brains of individuals with Alzheimer’s disease. [1] These fungal components, including those from common environmental fungi like Candida spp., Malassezia spp., Cladosporium spp. and Alternaria spp. have been identified in the brain tissues and cerebrospinal fluid of Alzheimer’s patients. This finding suggests a potential link between fungal infections or colonization and the pathogenesis of Alzheimer’s disease.

Obvious Evidence of Fungi or Mold Reaching the Brain: Psilocybin as a Psychedelic Recreational Drug and Research Medication

“Magic Mushrooms” have been a schedule four psychedelic drug for ceremonial purposes dating back to civilizations, over thousands of years, from around the world.  In general, the effects include euphoria, visual and mental hallucinations, changes in perception, distorted sense of time, and perceived spiritual experiences. It can also cause adverse reactions such as nausea and panic attacks. 

Psylocybin

Mold Infection as a Trigger to Alzheimer’s

Mounting evidence suggests that fungal infections, particularly chronic or recurring infections, may act as triggers or contribute to the development of Alzheimer’s disease. [2] The presence of fungi in the brain could lead to chronic inflammation and activation of the immune system, potentially contributing to the accumulation of amyloid-beta plaques and neurofibrillary tangles—hallmarks of Alzheimer’s pathology. However, it is important to note that the exact mechanisms underlying this relationship are still being investigated.

Impact of Mold Toxins and Inflammation[3]

Fungi produce various toxins, known as mycotoxins, which can have detrimental effects on human health. Some mycotoxins have been found to promote inflammation and oxidative stress in the brain, potentially exacerbating the neurodegenerative processes seen in Alzheimer’s disease. Additionally, the chronic inflammation induced by fungal infections or colonization could contribute to neuronal damage and cognitive decline. Understanding the role of these toxins and the resulting inflammation is crucial for unraveling the fungi-Alzheimer’s connection.[4]

Microbiome and Immune System Dysregulation

The human microbiome, including the fungal population, has gained attention for its potential influence on various aspects of health, including the brain. Alterations in the gut or respiratory fungal communities may disrupt the delicate balance of the microbiome and trigger immune system dysregulation. This dysregulation, coupled with an impaired blood-brain barrier, could facilitate the entry of fungal components into the brain, potentially influencing Alzheimer’s disease progression. [2]

Future Research and Implications Between Mold and Alzheimer’s

While the link between fungi and Alzheimer’s disease is still in its early stages of exploration, the growing body of evidence highlights the importance of further research. Investigating the potential causative role of fungi in Alzheimer’s could lead to novel therapeutic strategies aimed at targeting fungal infections, modulating the immune response, or even leveraging antifungal treatments. Additionally, understanding the interplay between the gut microbiome, fungi, and Alzheimer’s may reveal new avenues for prevention and management of this complex disease.


Conclusions

The emerging research on the relationship between mold and Alzheimer’s disease offers intriguing insights into potential contributing factors for this debilitating condition. While more studies are needed to establish a causal link, maintaining a safe home environment is an important part of mold hygiene.  Maintaining clean air in your bedroom while you sleep with a HEPA Air Purifier will allow your glymphatic system to detoxify your brain nightly. Read more about selecting the right HEPA Air Purifier HERE.

BioBalance provides multiple solutions to systemically remediate mold, allergens, and particulates from your home.   In the event the home has a water intrusion or moisture problem, repair the source of moisture first.  Otherwise, remediation efforts will be unsuccessful. 

HavenMist can be a quick maintenance solution to reduce mold in a space.  It can be done in minutes followed by a good vacuuming and wipe down.  This will reduce mold counts in a room almost immediately.  HavenFog can provide a very thorough removal of mold via filling the air volume in a space with a dense fog that exceeds the space volume.  This forces the non-toxic botanical solution to reach all surface areas and penetrate all corners and crevices.  The fog will collide and agglomerate or clump mold and allergens until the force of gravity takes all remains to the ground.  A thorough small particulate clean up protocol will remove all remains from the space.

Introduction To Haven

  1. Pisa, Diana. Et. al. “Direct Visualization of Fungal Infection in Brains from Patients with Alzheimer’s Disease”.Journal of Alzheimer’s Disease.  June 23, 2014.
  2. Phuna, Z. X., &Madhavan, P. ” A closer look at the mycobiome in Alzheimer’s disease: Fungal species, pathogenesis and transmission.” European Journal of Neuroscience,  January 19, 2022.
  3. Maryam Vasefi. et.al. “Environmental toxins and Alzheimer’s disease progression.” Neurochemistry International. December 2020
  4. Harding, Cheryl F.et.al. “Mold inhalation causes innate immune activation, neural, cognitive and emotional dysfunction”.  Brain, Behavior, and Immunity.  July, 2020,

 

"Toxic Mold in the News" Series publishing weekly starting mid-November 2023.

Headline News

Toxic Mold in the News Part 1:

Mold in the News Series Introduction

November 17, 2023

Headline News

Toxic Mold in the News Part 2:

Fungal Infections Are a Growing Concern

November 24, 2023

Headline News

Toxic Mold in the News Part 3:

Candida Infections in the Brain

December 1, 2023

Headline News

Toxic Mold in the News Part 4:

Fungal Brain Infections

December 8, 2023

Headline News

Toxic Mold in the News Part 5:

The Link Between Mold Illness and Alzheimer’s

December 15, 2023

Headline News

Toxic Mold in the News Part 6:

2023 Fungal Meningitis Outbreak

December 22, 2023

Headline News

Toxic Mold in the News Part 7:

Common Plant Fungus Cross Species to Humans

December 29, 2023

Product Recalls

Toxic Mold in the News Part 8:

Product Recalls Due to Mold

January 5, 2023